Related Experiment Video
Updated: Jul 16, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
Published on: October 17, 2025
Significant drug interaction: phenytoin toxicity due to erlotinib
Tal Grenader1, Maya Gipps, Linda Shavit
1Department of Oncology, Shaare Zedek Medical Center, Jerusalem, Israel. talgrenader65@hotmail.com
Abstract:
Brain metastases are a frequent finding in patients with advanced non-small cell lung cancer and concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor is necessary in many cases. Anticonvulsants have clinically significant interactions with other drugs used in brain tumor patients. We report a case in which a potential drug interaction resulted in elevated phenytoin levels after initiation of erlotinib therapy in a patient who was receiving phenytoin.
More Related Videos
Related Concept Videos
Drug toxicity: Drug–Drug Interaction
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Pharmacokinetics: Drug–Drug Interactions
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Drug toxicity: Idiosyncratic Reactions
Drug Toxicity: Dose-Dependent Reactions

