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Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

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Published on: March 15, 2024

Emotional and cognitive changes during adolescence.

Deborah Yurgelun-Todd¹

¹Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. ytodd@mclean.harvard.edu

Current Opinion in Neurobiology

|March 27, 2007

Summary

Adolescence involves significant brain development, particularly in the prefrontal cortex, enhancing cognitive and emotional regulation skills. Magnetic resonance imaging reveals structural and functional brain changes during this critical developmental period.

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Last Updated: Jul 16, 2026

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

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Published on: March 15, 2024

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood

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Published on: February 11, 2017

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Neuroscience
Developmental Psychology
Cognitive Science

Background:

Adolescence is a crucial phase for neurobiological maturation affecting cognition and behavior.
Understanding brain changes during this period is vital for explaining adolescent development.

Purpose of the Study:

To investigate the neurobiological changes occurring during adolescence using advanced imaging techniques.
To correlate structural and functional brain development with cognitive and emotional maturation.

Main Methods:

Utilized magnetic resonance imaging (MRI) for structural and functional brain analysis.
Examined changes in regional brain volumes and network processing during adolescence.

Main Results:

Observed progressive and regressive changes in specific brain regions, with delayed maturation in the prefrontal cortex.
Demonstrated parallel increases in abstract reasoning, attention, and emotional regulation.
Functional imaging showed developmental shifts in frontal cortical network processing.

Conclusions:

Adolescent brain development involves significant structural and functional reorganization, especially in frontal regions.
The prefrontal cortex plays an increasing regulatory role, contributing to cognitive and affective changes.
These neurobiological shifts underpin the characteristic behaviors and abilities of adolescence.