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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jun 21, 2026

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

Mediante: a web-based microarray data manager.

Kevin Le Brigand¹, Pascal Barbry

¹CNRS and University of Nice Sophia Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097, 06560 Sophia Antipolis, France.

Bioinformatics (Oxford, England)

|March 27, 2007

Summary

This summary is machine-generated.

Mediante is a MIAME-compliant data manager for microarray experiments. It integrates production, data storage, and project management, aiding quality control and public data submission.

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Area of Science:

* Bioinformatics and Computational Biology
* Molecular Biology and Genomics

Background:

* Microarray data management is crucial for reproducibility and data sharing.
* Existing tools may lack comprehensive features for microarray project lifecycle management.

Purpose of the Study:

* To present Mediante, a Java Enterprise Edition (J2EE) three-tier application for microarray data management.
* To integrate microarray production, experimental data repository, and project management functionalities.
* To facilitate quality control and submission of microarray data to public repositories.

Main Methods:

* Developed as a J2EE three-tier application.
* Integrated a management system for long oligonucleotide microarray production.
* Incorporated an experimental data repository for diverse microarray types.
* Designed a user interface for microarray project management.
* Implemented quality control tools for hybridizations.

Main Results:

* Mediante provides a unified platform for managing microarray projects from production to data submission.
* The system supports both in-house and commercial microarray data.
* Quality control tools enhance data reliability.
* Facilitates submission of validated data to public repositories, ensuring MIAME compliance.

Conclusions:

* Mediante offers a comprehensive solution for microarray data management.
* Enhances data quality, accessibility, and compliance with MIAME standards.
* Supports the entire lifecycle of microarray experiments.