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Updated: Jul 16, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
The fatter the better? Perivascular adipose tissue attenuates vascular contraction through different mechanisms
1Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der J.W. Goethe-Universität, Frankfurt am Main, Germany. r.brandes@em.uni-frankfurt.de
Abstract:
Adipose tissue releases several hormones and autacoids and expansion of the adipose tissue and excessive obesity is a risk factor for hypertension. Perivascular adipose tissue, on the other hand, has been reported to lower the vascular tone through the release of a transferable, thermosensitive, non-lipid factor. In this issue of the British Journal of Pharmacology, Gao et al. (2007) report that a factor generated by the adipose tissue also stimulates the generation of NO by endothelium and that NO is the predominant mediator of adipose tissue-induced relaxation in endothelium-intact vessels.
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