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Sampling Strategies and Processing of Biobank Tissue Samples from Porcine Biomedical Models

Sampling Strategies and Processing of Biobank Tissue Samples from Porcine Biomedical Models

Published on: March 6, 2018

Advances in swine biomedical model genomics.

Joan K Lunney¹

¹APDL, BARC, ARS, United States Department of Agriculture, Beltsville, MD 20705, USA. jlunney@anri.barc.usda.gov

International Journal of Biological Sciences

|March 27, 2007

Summary

Swine are valuable biomedical models due to physiological similarities with humans. Genomics advances, including the swine genome sequence, enhance their utility for studying diseases like melanoma and infectious diseases, including PRRS.

Area of Science:

Biomedical Science
Genomics
Comparative Medicine

Background:

Swine serve as a critical mammalian model for human studies due to anatomical, physiological, and developmental similarities.
The pig model offers advantages for timed studies, advanced imaging, and tissue sampling, facilitating comparative analyses.

Purpose of the Study:

To provide an update on swine biomedical models and the role of genomics in their development.
To highlight genomic approaches for studying diseases in swine models.
To explore genomic strategies for controlling Porcine Reproductive and Respiratory Syndrome (PRRS) and their human health applications.

Main Methods:

Review of existing literature on swine biomedical models and genomic applications.
Discussion of genomic studies focusing on melanoma and infectious disease resistance in swine.

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Exploration of genomic tools and comparative analyses leveraging the swine genome sequence.

Main Results:

Swine models exhibit high homology with human genome structure, facilitating genomic research.
Genomic approaches are instrumental in advancing comparative analyses and understanding disease mechanisms.
Genomic strategies show potential for developing novel control methods for PRRS and informing human viral disease studies.

Conclusions:

The pig is an excellent biomedical model for humans, enhanced by genomic advancements.
Genomic tools and studies are crucial for probing swine models and understanding disease.
Genomic insights from swine research have implications for both animal and human health, particularly in infectious diseases.