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Experimental studies on equine herpesvirus type 1 infections
Journal of Reproduction and Fertility. Supplement
|October 1, 1975
Summary
Equine herpesvirus-1 (EHV-1) from fetal origins showed greater growth and broader host range than respiratory strains. Fetal EHV-1 infected horses more easily, caused more abortions, and increased environmental shedding.
Area of Science:
- Equine Virology
- Infectious Disease Research
- Animal Health
Background:
- Equine herpesvirus-1 (EHV-1) is a significant pathogen in horses.
- Understanding EHV-1 strain virulence is crucial for disease control.
- Previous studies suggest variations in EHV-1 pathogenicity.
Purpose of the Study:
- To compare the biological characteristics of EHV-1 isolates from equine fetuses versus respiratory diseases.
- To evaluate the infectivity and shedding potential of different EHV-1 strains in horses.
Main Methods:
- In vitro tissue culture assays to assess viral growth and host range.
- In vivo experimental infection of partially immune horses with fetal and respiratory EHV-1 isolates.
- Monitoring clinical signs, viral shedding, and abortion rates.
Main Results:
- Fetal EHV-1 isolates demonstrated superior growth and a wider tissue culture host range compared to respiratory isolates.
- The fetal isolate (F/304) infected horses more readily and exhibited enhanced growth in the nasopharynx.
- Fetal EHV-1 was more likely to induce abortion and resulted in greater environmental virus excretion.
Conclusions:
- EHV-1 strains of fetal origin possess enhanced virulence characteristics.
- These findings highlight the distinct pathogenic potential of EHV-1 based on origin.
- Implications for EHV-1 transmission dynamics and disease management strategies.