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Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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Related Experiment Video

Updated: Jul 16, 2026

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Endothelial progenitor cells for postnatal vasculogenesis.

Masamichi Eguchi1, Haruchika Masuda, Takayuki Asahara

  • 1Department of Regenerative Medicine Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259-1193, Japan.

Clinical and Experimental Nephrology
|March 27, 2007
PubMed
Summary

Endothelial progenitor cells (EPCs) from bone marrow circulate and target sites of new blood vessel growth. These cells show therapeutic potential for cardiovascular ischemic diseases through vasculogenesis.

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Last Updated: Jul 16, 2026

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

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Published on: April 13, 2012

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
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Published on: September 14, 2017

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells
09:24

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Published on: September 18, 2019

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Endothelial progenitor cells (EPCs) originate in bone marrow and circulate systemically.
  • EPCs increase with cytokine stimulation or tissue ischemia.
  • These cells migrate to and integrate into sites of neovascularization.

Purpose of the Study:

  • To review the fundamental biology of EPCs.
  • To highlight the therapeutic potential of EPCs for cardiovascular ischemic diseases.
  • To discuss EPCs as a cell-based strategy for regenerative therapy.

Main Methods:

  • Literature review of EPC biology and therapeutic applications.
  • Analysis of EPC homing, incorporation, and vasculogenesis mechanisms.
  • Synthesis of current research on EPCs in cardiovascular regeneration.

Main Results:

  • EPCs possess inherent properties for neovascularization.
  • EPCs can be augmented by specific biological stimuli.
  • EPCs contribute to therapeutic angiogenesis via vasculogenesis.

Conclusions:

  • EPCs represent a promising cell source for treating ischemic cardiovascular conditions.
  • Understanding EPC biology is crucial for developing effective cell-based regenerative therapies.
  • EPC-based strategies offer a novel approach to cardiovascular disease treatment.