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Related Experiment Videos

Coating formulations for microneedles.

Harvinder S Gill1, Mark R Prausnitz

  • 1Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332-0535, USA.

Pharmaceutical Research
|March 27, 2007
PubMed
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Researchers developed new methods for coating microneedles to improve drug delivery. These advancements enable uniform, thick coatings and composite layers for diverse therapeutic applications.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Microneedle technology offers a minimally invasive approach for transdermal drug delivery.
  • Developing effective coating formulations is crucial for achieving desired drug loading and release profiles.
  • Controlling coating uniformity and thickness on microneedle arrays presents significant challenges.

Purpose of the Study:

  • To establish a framework for designing microneedle coating formulations for uniform and thick coatings.
  • To explore strategies for creating composite coatings and delivering liquid formulations.
  • To control the mass of therapeutic agents deposited on microneedles.

Main Methods:

  • Microneedles fabricated via laser-cutting and dip-coated with various formulations (aqueous, organic, molten).

Related Experiment Videos

  • Riboflavin (vitamin B2) mass determined as a function of coating and microneedle parameters.
  • Coated microneedles tested for delivery efficacy in porcine skin models.

    • Main Results:

    • Excipients influencing surface tension and viscosity optimized coating uniformity and thickness.
    • Hydrophilic and hydrophobic molecules, including model proteins, were uniformly coated.
    • Pocketed microneedles enabled selective filling for difficult-to-coat substances and composite layer formation.
    • Coating mass correlated with riboflavin concentration, dip number, and array density.
    • Coatings dissolved rapidly in skin without surface loss.

    Conclusions:

    • Microneedle design and coating formulations can be tailored for specific drug delivery needs.
    • This research provides a rational basis for developing advanced microneedle-based therapeutics.
    • The developed strategies facilitate controlled drug loading and efficient delivery via microneedles.