Related Experiment Video
Updated: Jul 16, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
[Lipid peroxidation and antioxidant defense in patients with ischemic heart disease: correction with free-load
Aim:
To study changes in lipid peroxidation-antioxidant defense (LPO-AOD) system in patients with various clinical forms of ischemic heart disease (IHD) in response to free-load bicycle exercise (FBE).
Material And Methods:
A total of 185 IHD patients aged 46-76 years (mean age 68.4 +/- 1.6 years, 99 males and 86 females) were randomized into two groups. Group 1 consisted of 90 patients who received standard medication and FBE. Group 2 of 95 patients received only standard medication. Thirty four healthy controls entered the control group. Each group was divided into subgroups by a clinical form of IHD. LPO was assessed by plasma levels of lipid peroxide (LP), malonic dialdehyde (MDA), AOD--by total antioxidant activity (TAA) in plasma red cells, activity of superoxide dismutase (SOD) and catalase in red cells.
Results:
Irrespective of a clinical form of IHD, conventional therapy stimulated AOD and decreased LP by 15.1% (p < 0.05), MDA by 21.4% (p < 0.05), on the average, but still these parameters were higher than in healthy controls. The addition of FBE reduced AOD to the levels of that of healthy controls, enhanced AOD the activation of which depended on a clinical form of IHD.
Conclusion:
FBE elevates antiradical potential of blood in trained patients with different clinical forms of IHD. The highest effect was observed on enzymatic link of the AOD system.
Related Concept Videos
Atherosclerosis III: Management
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Peripheral Artery Disease III: Interprofessional Care
Coronary Artery Disease IV: Preventive Measures
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Angina IV: Management

