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Updated: Jul 16, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions
R L Katona1, P Loyer, Sarah K Roby
1Department of Genetics and Tumor Cell Biology, MS350, Room D5003, St. Jude Children's Research Hospital 332 N. Lauderdale, Memphis, TN 38105-2794, USA. katona@brc.hu
Abstract:
Cyclin C is a highly conserved protein that is involved in divergent cellular processes. The exact roles of its isoforms are presently not very well defined and it is possible that there is a functional divergence amongst them. We therefore sought to assess the expression pattern of cyclin C1 and C2 isoforms in various human tissues and in cell cycle by using real-time PCR experiments. Our findings strongly suggest that the C2 isoform may play a presently unexplored and important role in mammalian testis and probably this isoform is the one that is mainly implicated in cell cycle regulation.
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