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Related Experiment Video

Updated: Jul 16, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

A vortex pump-based optically-transparent microfluidic platform for biotech and medical applications.

Kin Fong Lei1, Wing Cheung Law, Yick-Keung Suen

  • 1Centre for Micro and Nano Systems, The Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
|March 28, 2007
PubMed
Summary

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This study presents an automated polymer microfluidic system with a surface plasmon resonance (SPR) biosensor for detecting biomolecules and monitoring cell adhesion. This innovation shows promise for bio-molecule detection and drug discovery applications.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Microfluidic systems offer miniaturized platforms for biological analysis.
  • Surface Plasmon Resonance (SPR) biosensors are sensitive tools for detecting molecular interactions.
  • Polymer-based microfluidics present advantages in cost and biocompatibility over traditional materials.

Purpose of the Study:

  • To develop an automated polymer-based microfluidic system integrated with an SPR biosensor.
  • To demonstrate the system's capability for detecting specific biomolecule binding.
  • To qualitatively monitor cell adhesion and assess its potential in drug discovery and biomedical applications.

Main Methods:

  • Integration of micropumps, microchannels, and an SPR biosensor into a single polymethyl methacrylate (PMMA) microfluidic device.

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Last Updated: Jul 16, 2026

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  • Utilizing PMMA as an optically transparent substrate for SPR bio-detection.
  • Conducting experiments involving the reaction between Bovine Serum Albumin (BSA) and its antibody, and monitoring living cell activities.

    • Main Results:

    • Successful demonstration of specific biomolecule binding detection using the integrated SPR biosensor.
    • Qualitative monitoring of cell adhesion on the sensor surface was achieved.
    • The system showed potential for real-time monitoring of biological processes.

    Conclusions:

    • The developed PMMA-based microfluidic system with an integrated SPR biosensor is feasible for bio-molecule detection and cell adhesion monitoring.
    • PMMA is a viable, low-cost, and biocompatible alternative to glass and silicon-glass for SPR-based microfluidic applications.
    • The system holds promise for commercialization in the field of bio-medical and chemical analysis.