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Human bocavirus in Iranian children with acute respiratory infections

Mohammadreza Naghipour1, Luis E Cuevas, Tahereh Bakhshinejad

  • 1Liverpool School of Tropical Medicine, Liverpool, UK.

Journal of Medical Virology
|March 28, 2007
PubMed

Insights

Human bocavirus (HBoV) was detected in 8% of Iranian children with acute respiratory infections. This finding suggests HBoV is a significant contributor to childhood respiratory illnesses, particularly in younger children.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Respiratory Medicine

Background:

  • Human bocavirus (HBoV), identified in 2005, is increasingly recognized as a cause of acute respiratory infections in children globally.
  • Previous studies indicate a worldwide distribution of HBoV, yet data from specific regions like Iran were limited.

Purpose of the Study:

  • To determine the frequency and clinical characteristics of HBoV infections in young Iranian children presenting with acute respiratory infections.
  • To investigate the seasonal patterns and potential co-infections associated with HBoV in this pediatric population.

Main Methods:

  • Nasopharyngeal specimens were collected from 261 children under 5 years old with acute respiratory infections in Rasht, Iran, during the winter of 2003-2004.
  • Polymerase chain reaction (PCR) and reverse transcription PCR (RT-PCR) were employed to detect HBoV and other common respiratory pathogens.
  • Clinical data, including age and hospitalization status, were analyzed in conjunction with HBoV detection.

Main Results:

  • HBoV was detected in 21 (8%) of the 261 children studied.
  • The virus was more prevalent in hospitalized children (12%) compared to outpatients (4%) (P < 0.05).
  • The majority of HBoV-infected children were under 2 years old (81%), with a notable proportion under 1 year (33%). A seasonal peak was observed in February, suggesting autumn and early winter circulation. Seven children had co-infections with other respiratory viruses like RSV, adenovirus, or influenza A.

Conclusions:

  • HBoV is a common pathogen associated with acute respiratory infections in young Iranian children.
  • The findings highlight the importance of considering HBoV in the differential diagnosis of pediatric respiratory illnesses, especially in younger age groups.
  • Further research is warranted to understand the full clinical impact and epidemiological trends of HBoV in different geographical settings.

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