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A practical solid-phase synthesis of Glu7-phalloidin and entry into fluorescent F-actin-binding reagents

Laura A Schuresko1, R Scott Lokey

  • 1Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA.

Angewandte Chemie (International Ed. in English)
|March 28, 2007
PubMed
Abstract

No abstract available in PubMed .

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Actin Polymerization01:42

Actin Polymerization

Actin polymerization occurs through the head-to-tail association of binding sites on monomeric actin or G-actin to form filamentous or F-actin. The polymerization can be divided into three phases ̶  nucleation, elongation, and steady-state phase.
The nucleation phase involves forming a stable nucleus consisting of three actin monomers to form a new actin filament. Actin-binding proteins such as formins and Arp2/3 complex help filament growth post-nucleation. The Formins form straight actin...