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Updated: Jul 16, 2026

Using Cyclic Voltammetry, UV-Vis-NIR, and EPR Spectroelectrochemistry to Analyze Organic Compounds
Published on: October 18, 2018
Experimental/computational study of the electrochemical oxidation of cyclooctatetraene in protic media. Solvent
Grayson Connors1, Xin Wu, Albert J Fry
1Chemistry Department, Wesleyan University, Middletown, Connecticut 06459, USA.
Abstract:
[reaction: see text] Electrochemical oxidation of cyclooctatetraene (COT) in methanol affords a ring-contracted acetal in high yield. Ring contraction is only a minor process in acetic acid. Ab initio computational methods were applied to understand and explain the effect of solvent. The computations show considerable differences between the thermodynamic and kinetic preferences for ring contraction vs bicyclo[4.2.0] product formation.
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