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On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressor

Paul Anderson1, Nancy Kedersha

  • 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA.

Molecular Cell
|March 28, 2007
PubMed

Insights

Steroid receptor coactivator-3 (SRC-3) has a new cytoplasmic role. It activates translational silencers, inhibiting the production of proinflammatory cytokines.

Area of Science:

  • Molecular biology
  • Cellular signaling

Background:

  • Steroid receptor coactivator-3 (SRC-3) is known for its role in nuclear hormone receptor signaling.
  • The precise cytoplasmic functions of SRC-3 remain largely unexplored.

Discussion:

  • Yu et al. (2007) identified a novel cytoplasmic function for SRC-3.
  • SRC-3 directly activates the RNA-binding proteins TIA-1 and TIAR.
  • These proteins act as translational silencers, inhibiting mRNA translation.

Key Insights:

  • SRC-3's cytoplasmic activity regulates gene expression post-transcriptionally.
  • Activation of TIA-1 and TIAR by SRC-3 leads to the inhibition of proinflammatory cytokine translation.
  • This finding reveals a new mechanism controlling inflammatory responses.

Outlook:

  • Further investigation into SRC-3's cytoplasmic role in inflammation is warranted.
  • This discovery may open new therapeutic avenues for inflammatory diseases.

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