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Systematic error arising from 'Sequential' Standard Addition Calibrations: quantification and correction.

Richard J C Brown1, Matthew R Roberts, Martin J T Milton

  • 1Analytical Science Group, National Physical Laboratory, Teddington, Middlesex, TW110LW, UK. richard.brown@npl.co.uk <richard.brown@npl.co.uk>

Analytica Chimica Acta
|March 28, 2007
PubMed
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Sequential Standard Addition Calibration (S-SAC) can introduce systematic errors due to mass fraction ratios. A mathematical correction is proposed to improve accuracy in analytical chemistry methods.

Area of Science:

  • Analytical Chemistry
  • Electrochemistry

Background:

  • Sequential Standard Addition Calibration (S-SAC) is a common technique for determining analyte concentrations.
  • Potential systematic errors in S-SAC can affect the accuracy of analytical results.

Purpose of the Study:

  • To identify and quantify the systematic error in S-SAC.
  • To develop a mathematical model for this error.
  • To propose a correction method for S-SAC.

Main Methods:

  • Mathematical modeling of systematic error in S-SAC.
  • Experimental validation using anodic stripping voltammetry for lead determination.
  • Analysis of the relationship between mass fractions of standard and unknown solutions.

Main Results:

Related Experiment Videos

  • A systematic error in S-SAC was identified and mathematically described.
  • The error is directly related to the ratio of mass fractions in standard and unknown solutions.
  • Experimental results for lead determination confirmed the mathematical model.

Conclusions:

  • The identified systematic error can be corrected using the derived mathematical relationships.
  • A proposal for best practice in S-SAC is presented to enhance accuracy.
  • This work provides a method to improve the reliability of S-SAC in analytical measurements.