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Pancreatic cancer inhibition by specific knockdown of K-ras mutant allele expression

Eric J Bernhard1

  • 1Radiation Oncology and Biology, Radiation Biology Institute, Oxford University, Headington, Oxford, UK. eric.bernhard@rob.ox.ac.uk

Cancer Biology & Therapy
|March 28, 2007
PubMed
Abstract

No abstract available in PubMed .

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The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...