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Updated: Jul 16, 2026
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Intra-fraction dose delivery timing during stereotactic radiotherapy can influence the radiobiological effect
Martin J Murphy1, Peck-Sun Lin, Cihat Ozhasoglu
1Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA. mjmurphy@vcu.edu
Abstract:
The sequence of incremental dose delivery during a radiotherapy fraction can potentially influence the radiobiological effect. This would be most noticeable during the long fractions characteristic of hypo-fractionated stereotactic radiotherapy and radiosurgery. We demonstrate here the spatio-temporal variation of dose delivery by the CyberKnife to a lung tumor and propose strategies to reduce and/or correct for any resultant dose-time cytotoxic effects.
