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Highly effective contact antimicrobial surfaces via polymer surface modifiers.

Pinar Kurt1, Lynn Wood, Dennis E Ohman

  • 1Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 29, 2007
PubMed
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New antimicrobial coatings utilize polymer-surface modifiers (PSMs) for effective bacterial kill without biocide release. These coatings show high efficacy against Gram-positive and Gram-negative bacteria, addressing concerns about antibiotic resistance.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Antimicrobial Technology

Background:

  • Contact antimicrobial coatings are crucial for preventing infections.
  • Concerns exist regarding antibiotic resistance due to biocide-releasing coatings.
  • Developing effective, non-releasing antimicrobial surfaces is a priority.

Purpose of the Study:

  • To develop a novel concept for antimicrobial coatings based on thermodynamically driven surface concentration.
  • To create polymer-surface modifiers (PSMs) inspired by natural antimicrobial proteins.
  • To achieve effective bacterial inactivation without releasing biocides.

Main Methods:

  • Synthesized polyurethanes with specific soft block side chains (alkylammonium, trifluoroethoxy, or PEGlyted).
  • Tested PSMs as 100% coatings and as 2% additives in conventional polyurethane coatings.

Related Experiment Videos

  • Evaluated antimicrobial efficacy against Gram-negative (Pseudomonas aeruginosa, Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria using aerosol challenges and zone of inhibition tests.

    • Main Results:

    • PSMs demonstrated high efficacy against Gram-negative bacteria as 100% coatings.
    • A copolymer with 89 mol% trifluoroethoxy and 11 mol% C-12 alkylammonium side chains achieved 100% bacterial kill (Gram+/-) with 3.6-4.4 log reduction at 2 wt% loading.
    • Zone of inhibition tests confirmed no detectable biocide release from PSM-containing coatings.

    Conclusions:

    • The developed PSM concept effectively creates antimicrobial surfaces through surface concentration of active side chains.
    • This approach offers a promising strategy for developing non-releasing antimicrobial coatings.
    • The findings contribute to combating antibiotic resistance by providing a safe and effective alternative to biocide-releasing materials.