Endobronchitis by Scedosporium apiospermum in a child with cystic fibrosis
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Updated: Jul 16, 2026

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
Oscar Vázquez-Tsuji1, Teresita Campos Rivera, Adrián Rondán Zárate
1Laboratorio de Biología Molecular y Microscopía Electrónica, Facultad Mexicana de Medicina, Universidad La Salle, Mexico. ovztsuji@yahoo.com.mx
Abstract:
A case of endobronchitis by Scedosporium apiospermum in a child with cystic fibrosis is presented. The bronchial aspirate's cytology showed the presence of a large amount of septated-dichotomized hyphae. The bronchial aspirate's culture showed the presence of Scedosporium apiospermum in a pure culture of three consecutive samples. The scanning electron microscopy study of the mucosal surface revealed scarce mycelia with the presence of abundant conidiae. The transmission electron microscopy of the mucosa revealed inflammatory infiltrates constituted by macrophages, polymorphonuclear leukocytes, a lot of dichotomized mycelia and macrophages with hyphae and conidiae within the phagosomes. The patient was treated with amphotericin B and itraconazole.
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