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Updated: Jul 16, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
GNAS1 T393C polymorphism is associated with migraine.
A Oterino1, C Ruiz-Alegría, J Castillo
1Service of Neurology, University Hospital Marqués de Valdecilla (UC), Santander, Spain. aoterino@humv.es
The GNAS1 T393C gene variant is linked to a higher risk of migraine headaches. This genetic factor may explain why some migraine sufferers have heightened sensitivity in their sympathetic nervous system (SNS).
Area of Science:
- Genetics
- Neurology
- Physiology
Background:
- Migraineurs exhibit interictal sympathetic nervous system (SNS) hypofunctionality and hypersensitivity to adrenergic amines.
- The GNAS1 T393C polymorphism is known to influence SNS sensitivity in healthy individuals.
Purpose of the Study:
- To investigate the association between the GNAS1 T393C polymorphism and migraine risk.
- To explore the potential genetic basis for SNS hypofunctionality and hypersensitivity in migraine patients.
Main Methods:
- Case-control study involving 365 migraine patients (194 with aura) and 347 healthy controls.
- Analysis of GNAS1 T393C genotypes.
- Logistic regression and transmission disequilibrium tests were employed.
Main Results:
- A significant excess of the CC genotype was observed in migraineurs (31.2%) compared to controls (20.2%).
- The CC genotype conferred an approximately twofold increased risk for migraine (OR 1.79).
- In a family-based subgroup, the CC genotype showed an even higher risk (OR 2.20).
Conclusions:
- The GNAS1 T393C variant is associated with an increased risk of migraine.
- This finding suggests a potential genetic contribution to the sympathetic nervous system's altered sensitivity in migraine.
- Further research into the GNAS1 gene's role in migraine pathophysiology is warranted.
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