Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic variation and human aging: progress and prospects.

David Melzer1, Alison J Hurst, Tim Frayling

  • 1Peninsula Medical School, University of Exeter, Exeter, UK. david.melzer@pms.ac.uk

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|March 29, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chondrocalcinosis and the haemochromatosis-linked <i>HFE</i> C282Y homozygous variant in the UK Biobank.

EULAR rheumatology open·2026
Same author

Predictors of MRI-estimated brain iron deposition in dementia and Parkinson's disease-associated subcortical regions: Genetic and observational analysis in UK Biobank.

Journal of Alzheimer's disease : JAD·2025
Same author

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data.

EBioMedicine·2025
Same author

Mitochondrial DNA copy number associated dementia risk by somatic mutations and frailty.

GeroScience·2024
Same author

Blood-based multivariate methylation risk score for cognitive impairment and dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2024
Same author

Incidence of liver complications with hemochromatosis-associated HFE p.C282Y homozygosity: The role of central adiposity.

Hepatology (Baltimore, Md.)·2024
Same journal

Life-course metabolic vulnerability and chronic kidney disease risk after early-life famine exposure in Middle-aged and older chinese adults.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Global prevalence, trends, and dose-response associations of polypharmacy in older adults.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Global Burden and Temporal Prediction of Intestinal Obstruction (1990-2021) and the Relationship with Blood Metabolites: An Integrated Analysis of GBD and Mendelian Randomization.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Exercise Promotes Glutamate Transporter-Mediated Glutamate Uptake in the Striatum to Regulate MSN Plasticity and Alleviate Behavioral and Functional Impairments in PD Rats.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Adolescent Dietary Restriction Improves Cognition and Frailty in Aged Female Wistar Rats.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Frailty, polypharmacy, deprescribing and 23-hour activity: insights from a mouse model.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
See all related articles

Human genetics research is advancing our understanding of aging. This review focuses on genetic variants linked to longevity and healthy aging in humans, moving beyond animal models.

Area of Science:

  • Genetics
  • Gerontology
  • Molecular Biology

Background:

  • Decades of research show metabolic pathways influence aging in animal models.
  • Human aging is complex and requires human-specific genetic insights.
  • Understanding genetic factors is crucial for healthy aging and longevity.

Purpose of the Study:

  • To review human genetic variants associated with longevity.
  • To examine genetic associations with disease and healthy aging in older adults.
  • To highlight progress and methods in human aging genetics.

Main Methods:

  • Thematic review of existing literature.
  • Analysis of human genetic studies on longevity.
  • Synthesis of findings on genetic associates of aging and disease.

Related Experiment Videos

Main Results:

  • Progress in identifying human genetic variants linked to longevity is significant.
  • Evidence is emerging for genetic influences on healthy aging and disease in older populations.
  • Current data is fragmentary but robust methods are advancing the field.

Conclusions:

  • Human genetic studies are essential for understanding human aging.
  • Advances in methodology are accelerating discoveries in aging genetics.
  • Future research will further elucidate the genetic drivers of human longevity and healthy aging.