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Updated: Jul 16, 2026
Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Chemoselective derivatization of a bionanoparticle by click reaction and ATRP reaction
Qingbing Zeng1, Tao Li, Brandon Cash
1Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, SC 29208, USA.
Abstract:
Horse spleen apoferritin, the hollow protein shell derived from ferritin, a special biological nanoparticle, can be chemoselectively modified at the lysine residues, which affords a robust scaffold for further chemical reactions including Cu(i)-catalyzed azide-alkyne cycloaddition reaction and atom transfer radical polymerization reaction.
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