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Published on: February 20, 2017
Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents
Karl-Heinz Altmann1, Jürg Gertsch
1Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH), HCI H405, Wolfgang-Pauli-Str. 10, CH-8093, Zürich, Switzerland. karl-heinz.altmann@pharma.ethz.ch
Abstract:
This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to inhibit human cancer cell proliferation through a taxol-like mechanism. These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery.
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