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Published on: October 31, 2019
Bromoalterochromides A and A', unprecedented chromopeptides from a marine Pseudoalteromonas maricaloris strain KMM
Michael Speitling1, Olga F Smetanina, Tatyana A Kuznetsova
1Department of Organic and Biomolecular Chemistry, University of Gottingen, Tammannstrasse 2, D-37077 Gottingen, Germany.
Abstract:
The marine strain Pseudoalteromonas maricaloris KMM 636T was found to produce an inseparable mixture of two brominated yellow main pigments, bromoalterochromide A and A', in a ratio of 3: 1. Both pigments are Thr-Val-Asn-Asn-X pentapeptide lactones, where the amino group of Thr is acylated with 9-(3-bromo-4-hydroxyphenyl)-nona-2,4,6,8-tetraenoic acid, and X is aIle and Leu, respectively. They possess cytotoxic effects on developing eggs of the sea urchin Strongylocentrotus intermedius, but no antibiotic activity.
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