Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Polyunsaturated Fatty Acids (PUFAs) in the Primary Prevention of Allergic Diseases in Children: A Position Paper of the SIAIP Primary and Secondary Prevention of Allergic Diseases and Nutraceuticals Committees.

Nutrients·2026
Same author

Micronutrient status and growth outcomes in children with cow's milk allergy: beyond elimination diets.

Frontiers in nutrition·2026
Same author

Evidence-Based Clinical Recommendations for the Appropriate Use of Diagnostic Tests in Pediatric Allergology: Focus on Asthma, Rhinoconjunctivitis, and Keratoconjunctivitis Vernal.

Journal of clinical medicine·2026
Same author

NKG2A and NKp30 expression in NK cells correlates with preserved white matter and cortical thickness and reduced negative symptoms in psychiatric disorders.

Journal of affective disorders·2026
Same author

Emerging Paediatric Uses of Dupilumab Beyond Approvals.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Hypertransaminasemia Is a Marker of Severity in Children Hospitalized for Influenza.

Influenza and other respiratory viruses·2026

Related Experiment Video

Updated: Jul 16, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Sublingual immunotherapy: an update on immunologic and functional effects.

Giorgio Ciprandi1, Daniela Fenoglio, Ignazio Cirillo

  • 1University Hospital San Martino, Genoa, Italy. gio.cip@libero.it

Allergy and Asthma Proceedings
|March 30, 2007
PubMed
Summary

Sublingual immunotherapy (SLIT) modifies allergic responses by altering antibody production and immune cell balance. SLIT effectively induces regulatory T cells (T-reg.), crucial for managing allergies.

More Related Videos

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
07:04

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation

Published on: September 16, 2018

Related Experiment Videos

Last Updated: Jul 16, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
07:04

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation

Published on: September 16, 2018

Area of Science:

  • Immunology
  • Allergy Research
  • Immunotherapy

Background:

  • Specific immunotherapy (SIT) is the only treatment that can alter the natural course of allergic diseases.
  • Sublingual immunotherapy (SLIT) is an alternative administration route for SIT.
  • Allergic patients exhibit a deficiency in regulatory T cells (T-reg.).

Purpose of the Study:

  • To investigate the immunopathological changes induced by sublingual immunotherapy (SLIT).
  • To explore the role of T regulatory cells in SLIT's efficacy.
  • To understand how SLIT impacts allergen-specific antibody production and immune response patterns.

Main Methods:

  • Analysis of allergen-specific antibodies (IgE and IgG4) following SLIT.
  • Assessment of immune response shifts from Th2 to Th1 patterns.
  • Evaluation of T regulatory cell induction and function, including IL-10 production.

Main Results:

  • SLIT can lead to increased allergen-specific IgG4 and decreased IgE levels.
  • A shift towards a Th1-oriented immune response has been observed after SLIT.
  • SLIT demonstrates the ability to induce a specific T regulatory cell response, evidenced by IL-10 production.

Conclusions:

  • Sublingual immunotherapy (SLIT) effectively modulates key immunological parameters in allergic individuals.
  • The induction of T regulatory cells is a significant mechanism by which SLIT exerts its therapeutic effects.
  • SLIT represents a viable immunotherapy approach with the capacity to restore immune balance in allergies.