Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Silicon accumulation in dialysis patients.

H J Gitelman1, F R Alderman, S J Perry

  • 1Division of Nephrology, University of North Carolina School of Medicine, Chapel Hill 27599-7155.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 1, 1992
PubMed
Summary

Patients undergoing dialysis have elevated plasma silicon levels, primarily due to silicon in dialysis fluids and drinking water. This silicon accumulation did not appear to negatively impact patient health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.

Circulation·2001
Same author

Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.

The Journal of biological chemistry·2001
Same author

Neuronal expression of an FMRFamide-gated Na+ channel and its modulation by acid pH.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.

The Journal of biological chemistry·2001
Same author

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Teaching patient empathy: the ED visit program.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2000

Area of Science:

  • Nephrology
  • Clinical Chemistry
  • Environmental Health

Background:

  • End-stage renal disease (ESRD) patients on chronic dialysis therapy are susceptible to altered mineral metabolism.
  • Silicon is an element present in water and medical supplies, with potential implications for patients with impaired renal function.

Purpose of the Study:

  • To investigate plasma silicon concentrations in patients with ESRD undergoing chronic dialysis.
  • To identify sources and determinants of elevated silicon levels in this patient population.
  • To assess the health impact of silicon accumulation in dialysis patients.

Main Methods:

  • Measurement of plasma silicon concentrations in ESRD patients across different dialysis modalities (hemodialysis and peritoneal dialysis).
  • Analysis of silicon content in dialysis fluids and patient-consumed water sources (well water vs. municipal water).

Related Experiment Videos

  • Assessment of plasma silicon ultrafiltrability through dialysis membranes (Cuprophane).

    • Main Results:

    • Dialysis patients exhibited significantly elevated plasma silicon levels compared to normal concentrations (0.15 +/- 0.02 mg/L).
    • Plasma silicon levels strongly correlated with the silicon content of dialysis fluids used.
    • Hemodialysis patients consuming high-silicon well water had higher plasma silicon than those on lower-silicon municipal water.
    • Silicon ultrafiltrability through Cuprophane membranes was 79 +/- 2%.

    Conclusions:

    • Elevated silicon levels in dialysis fluids and high-silicon water consumption are key factors contributing to silicon accumulation in dialysis patients.
    • No overt adverse health effects were observed in the studied dialysis patients despite elevated silicon levels.