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B-cell lymphoma presenting as infiltrative renal disease
N E Mills1, A S Goldenberg, D Liu
1Department of Medicine, New York University Medical Center, NY 10016.
Summary
Acute renal failure can rarely signal non-Hodgkin
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Non-Hodgkin's lymphoma (NHL) rarely presents as acute renal failure.
- Renal insufficiency from lymphoma infiltration is uncommon, with few acute cases reported.
Observation:
- A case of acute renal failure secondary to diffuse bilateral renal infiltration by B-cell non-Hodgkin's lymphoma is presented.
- Key diagnostic indicators included elevated serum lactate dehydrogenase (LDH), lymphopenia, and homogenous bilateral renal enlargement on CT imaging.
Findings:
- The diagnostic triad of elevated LDH, lymphopenia, and CT findings suggested primary renal lymphoma.
- Renal biopsy, immunohistochemistry, and ultrastructural analysis confirmed the diagnosis.
Implications:
- This case highlights the importance of considering lymphoma in the differential diagnosis of acute renal failure.
- Early diagnosis through imaging and biopsy is crucial for timely intervention in primary renal lymphoma.