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Updated: Jul 16, 2026
08:38
Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
Published on: March 3, 2015
Iconix Biosciences, Inc
Mark R Fielden1, Donald N Halbert
1Iconix Biosciences, Inc., Molecular and Investigative Toxicology, 325 E Middlefield Road, Mountain View, CA 94043, USA. mfielden@iconixbiosciences.com
Pharmacogenomics
|March 30, 2007
Summary
Iconix Biosciences utilizes genomic technologies for faster, cost-effective drug candidate profiling. This toxicogenomics approach enhances toxicity testing accuracy and speed, aiming to reduce late-stage failures in drug development.
Area of Science:
- Pharmacology
- Toxicology
- Genomics
Background:
- Traditional toxicity testing is time-consuming and costly.
- High failure rates in late-stage drug development represent significant financial loss.
- Genomic technologies offer a novel approach to understanding drug compound safety.
Purpose of the Study:
- To introduce genomic technologies for profiling drug candidates.
- To improve the accuracy, sensitivity, and speed of toxicity testing.
- To establish toxicogenomics as a standard practice in pharmaceutical R&D.
Main Methods:
- Application of proprietary genomic technologies.
- Profiling of candidate drug compounds from early discovery to preclinical stages.
- Analysis of genomic data to predict potential toxicity.
Main Results:
- Faster and more cost-effective understanding of candidate drugs.
- Increased accuracy, sensitivity, and speed in toxicity testing.
- Potential to significantly reduce late-stage preclinical compound failures.
Conclusions:
- Genomic technologies are transforming drug discovery and development.
- Toxicogenomics offers a paradigm shift in preclinical safety assessment.
- Widespread adoption of toxicogenomics is expected to yield substantial returns on investment and improve drug development success rates.
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