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Evaluation of propofol-ketamine anesthesia for children undergoing cardiac catheterization procedures

Parthasarathi Gayatri1, Puthussery Raman Suneel, Prabhat K Sinha

  • 1Department of Anesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India. gayat100@hotmail.com

Journal of Interventional Cardiology
|March 30, 2007
PubMed

Insights

This study found that combining propofol with either 25 or 12.5 mcg/kg/min of ketamine is safe and effective for pediatric cardiac catheterization procedures (CCP). Lower ketamine doses resulted in faster awakening times without compromising safety.

Area of Science:

  • Pediatric Anesthesiology
  • Cardiovascular Procedures
  • Pharmacology

Background:

  • Cardiac catheterization procedures (CCP) in children require safe and effective anesthesia.
  • Continuous intravenous infusions of propofol and ketamine are used for pediatric sedation.
  • Optimizing anesthetic combinations for CCP is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the safety and efficacy of continuous intravenous propofol-ketamine combinations for pediatric CCP.
  • To compare two different doses of ketamine when combined with propofol during CCP.
  • To assess hemodynamic stability, airway compromise, and recovery times.

Main Methods:

  • A prospective randomized study involving 32 children undergoing CCP.
  • Group 1 received propofol (25 mcg/kg/min) + ketamine (25 mcg/kg/min).
  • Group 2 received propofol (25 mcg/kg/min) + ketamine (12.5 mcg/kg/min).

Main Results:

  • No significant differences in patient demographics or procedure characteristics between groups.
  • Both anesthetic combinations were safe, with no hemodynamic instability, airway issues, or desaturation.
  • Lower ketamine doses (12.5 mcg/kg/min) led to significantly faster awakening times (P < 0.05).
  • Increased movement was observed with lower ketamine doses, but not statistically significant.

Conclusions:

  • Continuous intravenous administration of propofol with either 25 or 12.5 mcg/kg/min ketamine is safe and effective for pediatric CCP.
  • The lower ketamine dose (12.5 mcg/kg/min) offers a potential advantage with faster recovery.
  • Both regimens provide adequate anesthesia for pediatric cardiac procedures.

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