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Updated: Jul 16, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
The impact of bipolar disorder upon work functioning: a qualitative analysis
Erin E Michalak1, Lakshmi N Yatham, Victoria Maxwell
1Division of Mood Disorders, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. emichala@interchange.ubc.ca
Bipolar disorder (BD) significantly impacts work functioning, causing issues like job instability and interpersonal problems. Understanding these subjective experiences is crucial for developing better support and assessment tools for individuals with BD.
Area of Science:
- Psychiatry
- Occupational Health
- Qualitative Research
Background:
- Bipolar disorder (BD) is known to negatively affect occupational functioning.
- Quantitative studies show low employment rates in BD patients, but lack insight into specific work impacts and subjective experiences.
- There's a need to understand the complex relationship between BD and work for better quality of life measures.
Purpose of the Study:
- To explore the subjective experiences of individuals with bipolar disorder (BD) regarding their work functioning.
- To identify specific ways BD symptoms affect work and how these effects are interpreted by patients.
- To inform the development of a disease-specific quality of life measure for BD.
Main Methods:
- Conducted 52 qualitative interviews with 35 individuals with BD, 5 caregivers, and 12 healthcare professionals.
- Sample included individuals with diverse employment histories, from no work to stable professional positions.
- Interviews were audio-recorded, transcribed verbatim, and analyzed thematically.
Main Results:
- Five key themes emerged regarding BD's impact on work: continuity of work history, loss, workplace illness management, stigma/disclosure, and interpersonal difficulties.
- Respondents described how depression and hypo/mania symptoms manifest in the workplace.
- The findings highlight the varied and intermittent nature of BD's effects on work.
Conclusions:
- Traditional BD outcome measures focus on clinical symptoms, but functioning, especially work ability, is increasingly important.
- Qualitative data reveals the complex, varied, and intermittent impact of BD on occupational functioning.
- Developing precise measures of occupational functioning is essential for the BD population.
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