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Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response

Dina Mascolo1, Pasquale Barba, Piergiuseppe De Berardinis

  • 1Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Naples, Italy.

FEMS Immunology and Medical Microbiology
|March 30, 2007
PubMed

The Ovalbumin(257-264) CTL epitope on the major coat protein of the filamentous bacteriophage in different antigen formulations was displayed and the immune response in C57BL6/J mice studied. The display of single cytotoxic epitope on the surface of the virion is sufficient to induce priming and sustain long-term major histocompatibility complex class I restricted cytotoxic T lymphocytes response in vivo. The filamentous bacteriophage is a versatile carrier able to display simultaneously either single or multiple epitopes and can elicit a cellular response carrying very little peptide (<1.5 microg).

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