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Updated: Jul 16, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
Published on: June 7, 2018
Early prediction of anthracycline induced cardiotoxicity
Bedirhan Erkus1, Selda Demirtas, Aysegul Akbay Yarpuzlu
1Department of Biochemistry, Faculty of Medicine, Ankara University, Turkey.
Aim:
The purpose of this study is to evaluate echocardiographically determined cardiac functions with serum levels of brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and total antioxidant status (TAOS) in childhood leukemia treated with chemotherapeutics containing anthracyclines.
Methods:
A study group of 29 patients who have been followed for acute lymphoblastic leukemia (ALL) and administered a treatment protocol containing chemotherapy of anthracyclines were included in the analysis. Levels of BNP, cTnI and TAOS were studied in serum samples of the patients.
Results:
We demonstrated that as the drug dosage increased, systolic ejection fraction (EF) and shortening fraction (FS) values decreased (EF r2=0.2327, FS r2=0.251). On the other hand, increased dosage of anthracycline therapy was associated with significant raise in plasma BNP levels (r2=0.246) and significant decrease in serum TAOS levels (r2=0.317) without any change in serum cTnI levels.
Conclusion:
Our study suggest that serum TAOS and BNP levels may be useful as an early and sensitive indicator of anthracycline induced cardiotoxicity.
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