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Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum

Kenji Masaki1, Mitsuru Hashimoto, Teruko Imai

  • 1Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-Honmachi, Kumamoto, Japan.

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|March 30, 2007
PubMed

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Carbohydrate Absorption

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Methods for Studying Drug Absorption: In situ

In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
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Protein Absorption

Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.
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Methods for Studying Drug Absorption: In vitro

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