Related Experiment Video

Updated: Jul 16, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

TNF-alpha antagonists: benefits beyond remission

Uma Mahadevan1

  • 1Department of Medicine, Center for Colitis and Crohn's Disease, University of California, San Francisco, San Francisco, California, USA.

Reviews in Gastroenterological Disorders
|March 30, 2007
PubMed

Medical options for Crohn's disease are expanding at an unprecedented rate. The anti-tumor necrosis factor-a (TNF-a) agents infliximab, adalimumab, and certolizumab pegol have proven efficacy for induction and maintenance of remission among patients with moderate to severe Crohn's disease. Anti-TNF therapy has also been successful in reducing the need for corticosteroids, closing fistulas, healing colonic mucosa, and reducing the number of hospitalizations and surgeries. With these tools, the goal of therapy in Crohn's disease may change from the management of symptoms to a change in the natural history of the disease.

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