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Inherited risk factors for deep venous thrombosis following total hip arthroplasty in Japanese patients: matched

Yoshiro Kiyoshige1, Shigeo Kure, Kaoru Goto

  • 1Department of Orthopaedic Surgery, Saiseikai Yamagata Hospital, 79-1 Oki-machi, Yamagata 990-8545, Japan.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
|March 30, 2007
PubMed

Insights

Reduced protein C activity may increase deep venous thrombosis (DVT) risk in Japanese patients undergoing total hip arthroplasty (THA). Common genetic factors in Caucasians were not significant predictors in this Japanese cohort.

Area of Science:

  • Orthopedic Surgery
  • Thrombosis Research
  • Genetics

Background:

  • Deep venous thrombosis (DVT) risk factors are well-established in Caucasians but less understood in Japanese populations.
  • Elective total hip arthroplasty (THA) is associated with DVT risk.
  • This study investigated DVT risk factors in Japanese patients post-THA.

Purpose of the Study:

  • To identify inherited predisposing risk factors for DVT in Japanese patients after THA.
  • To evaluate the relevance of known Caucasian DVT risk factors in a Japanese cohort.
  • To assess the role of protein C, protein S, antithrombin III, plasminogen, homocysteine, and specific genetic polymorphisms.

Main Methods:

  • A case-control study involving 60 patients who underwent THA, with 30 developing DVT and 30 serving as controls.
  • Patients were matched for age, sex, diagnosis (dysplastic hip osteoarthritis), and surgical side.
  • Assays for protein C, protein S, antithrombin III, plasminogen activity, homocysteine levels, and screening for Factor V Leiden, Factor II G20210A, and MTHFR C677T polymorphisms were performed.

Main Results:

  • Significantly reduced plasma protein C activity was observed in patients who developed DVT compared to controls.
  • No significant differences were found in protein S, antithrombin III, plasminogen activities, or homocysteine levels.
  • Screening for Factor V Leiden, Factor II G20210A, and MTHFR C677T polymorphisms revealed no significant associations with DVT risk.

Conclusions:

  • Established Caucasian genetic risk factors for DVT are not predictive in Japanese patients undergoing THA.
  • Reduced plasma protein C activity appears to be a potential risk factor for DVT in this population.
  • Further research is warranted to elucidate specific DVT risk factors in Japanese THA patients.
Abstract

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