Factors that influence characteristics of genetic biobanks

To identify demographic differences between patients who choose participation and patients who choose nonparticipation in genetic biobanks, and to explore reasons for nonparticipation.

Prospective study of hospitalized cardiovascular patients approached to participate in a genetic biobank, 300 nonparticipants and 299 participants, in the southwestern US.

Reasons for nonparticipation were explored. Logistic regression was performed to determine if gender, race or ethnicity, or age predicted nonparticipation.

Race or ethnicity and age were significantly different between participants and nonparticipants, but gender was not. Blood-sample collection was the main reason for declining participation.

Minority and older adults were less likely to participate. Understanding reasons for nonparticipation in this group might aid in the development of methods used to obtain a diverse population in biobanks.