Related Experiment Video
Updated: Jul 16, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
Striatal gray matter loss in Huntington's disease is leftward biased
Mark Mühlau1, Christian Gaser, Afra M Wohlschläger
1Department of Neurology, Technische Universität München, Munich, Germany. m.muehlau@neuro.med.tum.de
Abstract:
In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.
Related Concept Videos
Huntington Disease l: Introduction
Lateralization
Parkinson Disease ll: Pathophysiology
Parkinson Disease l: Introduction
Neural Regulation

