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Updated: Jul 16, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
Published on: October 6, 2022
Investigation of the scope of a Co-mediated O-->C ring-contraction
Simon J Meek1, Fabienne Pradaux, Emmanuel H Demont
1Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, United Kingdom.
Abstract:
A series of dihydropyrans bearing a dicobalthexacarbonyl moiety have been found to undergo an efficient Al-promoted O-->C ring-contraction process. This rearrangement reaction operates successfully for a broad range of substrates. Moreover, the potential of this approach for generating cyclopropanes from the corresponding dihydrofurans has been demonstrated.
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