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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

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Cowden disease: a review.

S Uppal¹, D Mistry, A P Coatesworth

¹Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Leeds, UK. uppalsandeep@yahoo.com

International Journal of Clinical Practice

|March 31, 2007

Summary

Cowden disease is a rare genetic disorder causing multiple growths in the body. This review covers its diagnosis, symptoms, genetic basis, and treatment options for better patient care.

Area of Science:

Medical Genetics
Oncology
Dermatology

Background:

Cowden disease is an inherited disorder characterized by hamartomatous and neoplastic lesions.
It affects multiple organs and tissues, posing significant diagnostic and management challenges.

Purpose of the Study:

To provide a comprehensive review of Cowden disease.
To outline diagnostic criteria, clinical manifestations, genetic factors, and current management strategies.

Main Methods:

Literature review of diagnostic criteria.
Analysis of clinical presentations.
Summary of genetic findings.
Review of management approaches.

Main Results:

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Detailed diagnostic criteria are established.

A wide spectrum of clinical signs and symptoms is observed.

Specific genetic mutations are linked to the disease.

Management involves surveillance and treatment of associated conditions.

Conclusions:

Accurate diagnosis relies on established criteria and genetic testing.
Multidisciplinary management is crucial for patients with Cowden disease.
Further research can improve understanding and therapeutic options.