Related Experiment Video

Updated: Jul 16, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
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Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

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Abnormal left ventricular diastolic filling in chronic thromboembolic pulmonary hypertension: true diastolic

Swaminatha V Gurudevan1, Philip J Malouf, William R Auger

  • 1Division of Cardiology, University of California Irvine School of Medicine, Irvine, California, USA.

Journal of the American College of Cardiology
|March 31, 2007
PubMed

Insights

Abnormal left ventricular (LV) filling in chronic thromboembolic pulmonary hypertension (CTEPH) is primarily due to low LV preload and underfilling, not chamber distortion. Pulmonary thromboendarterectomy (PTE) improves LV diastolic function by increasing preload.

Area of Science:

  • Cardiology
  • Pulmonary Hypertension
  • Echocardiography

Background:

  • Chronic thromboembolic pulmonary hypertension (CTEPH) often presents with abnormal left ventricular (LV) diastolic function.
  • The cause of this "impaired relaxation" (E

Purpose of the Study:

  • To investigate the underlying cause of abnormal LV Doppler diastolic filling characteristics in patients with CTEPH.
  • To determine if RV enlargement and LV distortion or low LV preload are responsible for the observed diastolic dysfunction.
Abstract

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