Preoperative characterisation of clear-cell renal carcinoma using iodine-124-labelled antibody chimeric G250 (124I-cG250) and PET in patients with renal masses: a phase I trial
- 1Memorial Sloan-Kettering Cancer Center, New York, NY, USA. chaitanya.divgi@uphs.upenn.edu
- 0Memorial Sloan-Kettering Cancer Center, New York, NY, USA. chaitanya.divgi@uphs.upenn.edu
Related Experiment Videos
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Iodine-124-labelled antibody chimeric G250 (124I-cG250) PET accurately identifies clear-cell renal carcinoma. This imaging technique helps stratify patients, predict tumor aggressiveness, and guide treatment decisions for kidney cancer.
Area Of Science
- Oncology
- Nuclear Medicine
- Radiopharmaceuticals
Background
- Preoperative tumor identification is crucial for effective renal cancer treatment.
- Carbonic anhydrase-IX is over-expressed in clear-cell renal carcinomas.
- Chimeric G250 antibody targets carbonic anhydrase-IX.
Purpose Of The Study
- To evaluate the efficacy of iodine-124-labelled antibody chimeric G250 ((124)I-cG250) PET in predicting clear-cell renal carcinoma.
- To assess the diagnostic accuracy of (124)I-cG250 PET for identifying the most common and aggressive renal tumor type.
Main Methods
- A pilot study involving 26 patients with renal masses scheduled for surgery.
- Patients received a single intravenous infusion of (124)I-cG250.
- Abdominal PET and CT scans were performed before surgery, with results graded for antibody uptake.
Main Results
- (124)I-cG250 PET accurately identified 15 out of 16 clear-cell carcinomas (94% sensitivity).
- All nine non-clear-cell renal masses were negative for the tracer (100% specificity).
- The study demonstrated high sensitivity (94%) and specificity (100%) for clear-cell renal carcinoma detection.
Conclusions
- PET imaging with (124)I-cG250 accurately identifies clear-cell renal carcinoma.
- A negative scan suggests a less aggressive tumor phenotype, aiding in treatment stratification.
- (124)I-cG250 PET can assist in differentiating tumor types and guiding clinical management.
Related Experiment Videos
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.