Skin color and mortality risk among men: the Puerto Rico Heart Health Program
Related Experiment Video
Updated: Jul 16, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Luisa N Borrell1, Carlos J Crespo, Mario R Garcia-Palmieri
1Mailman School of Public Health, Columbia University, New York, NY 10032, USA. lnb2@columbia.edu
Insights
Darker skin color was linked to higher mortality risk in urban Puerto Rican men, suggesting environmental factors influence health outcomes. This highlights potential disparities in cardiovascular disease (CVD) risk.
Area of Science:
- Epidemiology
- Public Health
- Social Determinants of Health
Background:
- Skin color is a complex trait potentially linked to health outcomes.
- Environmental and socioeconomic factors may influence mortality risk.
- Understanding these associations is crucial for public health interventions.
Purpose of the Study:
- To investigate the relationship between skin color and mortality in Puerto Rican men.
- To assess all-cause and cardiovascular disease (CVD)-related mortality risks.
- To examine these associations before and after adjusting for various risk factors.
Main Methods:
- Utilized data from 5,304 men in the Puerto Rican Heart Health Program (PRHHP).
- Ascertained mortality through hospital records, death certificates, and next-of-kin information.
- Analyzed associations between skin color and mortality, considering area of residence and adjusting for covariates.
Main Results:
- Darker-skinned men had higher age-adjusted mortality rates than lighter-skinned men.
- No overall association between skin color and all-cause or CVD mortality was found.
- In urban areas, dark-skinned men faced a 28% higher risk of all-cause mortality after adjustments, but no such link for CVD mortality.
Conclusions:
- Skin color may act as a proxy for environmental dynamics affecting mortality.
- Environmental factors, particularly in urban settings, may mediate the association between skin color and mortality risk.
- Further research is needed to elucidate the specific environmental influences.
Purpose:
To examine the association between skin color and all-cause and cardiovascular disease (CVD)-related mortality risk before and after adjusting for selected characteristics and risk factors, we used data on 5,304 men with information on skin color at Exam 3 of the Puerto Rico Heart Health program (PRHHP), a longitudinal study of the incidence of coronary heart disease in Puerto Rican men.
Methods:
Mortality was ascertained using hospital and physician records, postmortem records, death certificates, and information from the next of kin.
Results:
Dark-skinned men exhibited higher age-adjusted mortality rates than light skinned men (10.1 vs. 8.8/10,000 population). There was no association between skin color and all-cause and CVD-related mortality. However, the association between skin color and all-cause mortality varied with area of residence (p for interaction = 0.05). Among men living in urban areas, the risk of all-cause mortality was 28% (95% confidence interval, 1.02-1.61) greater among dark-skinned men than their light-skinned counterparts after adjusting for age, education, BMI, physical activity, and the presence of diabetes. There was no association between skin color and CVD mortality in urban men. Neither all-cause nor CVD mortality was associated with skin color among rural men.
Conclusion:
Our results suggest that skin color may be capturing environmental dynamics that may influence mortality risk among Puerto Rican men.
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Coronary Artery Disease IV: Preventive Measures
Relative Risk
Bias in Epidemiological Studies
Lifestyle Factors and Health
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...