Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 16, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Vagus nerve stimulation for refractory epilepsy: a Belgian multicenter study.

Veerle De Herdt1, Paul Boon, Berten Ceulemans

  • 1Reference Center for Refractory Epilepsy, Ghent University Hospital, Belgium. Veerle.Deherdt@UGent.be

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|March 31, 2007
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CMIP as a novel candidate gene for neurodevelopmental and neuropsychiatric disorders.

European journal of human genetics : EJHG·2026
Same author

Cerebral, spinal, ophthalmological and skeletal findings associated with abusive and non-abusive head injury in children under 2 years old: A systematic review.

Child abuse & neglect·2026
Same author

Kv7.2 loss-of-function causes early hyperexcitability and network remodelling.

Brain : a journal of neurology·2026
Same author

Exploratory decoding of TMS-EEG: Predicting TEP response to intermittent and continuous theta burst stimulation.

NeuroImage·2026
Same author

Longitudinal Phenotypic Trajectories in GNAO1-Related Disorders: Defining Disease Progression and Clinical Profiles.

Annals of neurology·2026
Same author

Chronic Subthreshold Cortical Stimulation for Paracentral Epilepsy-A Systematic Review.

Neuromodulation : journal of the International Neuromodulation Society·2026

Vagus nerve stimulation (VNS) effectively reduced monthly seizures by 51% in refractory epilepsy patients over a mean follow-up of 44 months. This adjunctive treatment demonstrated a 59% responder rate, confirming its long-term efficacy.

Area of Science:

  • Neurology
  • Epileptology
  • Neurosurgery

Background:

  • Vagus nerve stimulation (VNS) is an established add-on therapy for drug-resistant epilepsy.
  • It involves electrical stimulation of the vagus nerve via an implanted device.
  • Over 50,000 patients globally utilize VNS for epilepsy management.

Purpose of the Study:

  • To evaluate the long-term outcomes of VNS in patients with refractory epilepsy.
  • This retrospective study assessed VNS efficacy across seven Belgian epilepsy centers.
  • The study focused on sustained seizure reduction and responder rates.

Main Methods:

  • Inclusion criteria required at least 12 months of follow-up and seizure diaries.
  • Primary outcomes included reduction in monthly seizure frequency and the percentage of responders (≥50% seizure reduction).

More Related Videos

Implantation Surgery for Abdominal Vagus Nerve Stimulation and Recording Studies in Awake Rats
07:17

Implantation Surgery for Abdominal Vagus Nerve Stimulation and Recording Studies in Awake Rats

Published on: January 19, 2024

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
11:02

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

Related Experiment Videos

Last Updated: Jul 16, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Implantation Surgery for Abdominal Vagus Nerve Stimulation and Recording Studies in Awake Rats
07:17

Implantation Surgery for Abdominal Vagus Nerve Stimulation and Recording Studies in Awake Rats

Published on: January 19, 2024

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
11:02

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

  • Data were collected retrospectively from 138 patients.

    • Main Results:

    • The mean follow-up period was 44 months.
    • A 51% overall reduction in mean monthly seizure frequency was observed.
    • The responder rate was 59%, with 9% achieving seizure freedom.

    Conclusions:

    • Long-term VNS use in Belgium confirms its efficacy as an adjunctive treatment for refractory epilepsy.
    • VNS provides significant seizure reduction and is a valuable therapeutic option.
    • The study supports the continued use of VNS for managing difficult-to-treat epilepsy cases.