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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama

Masaaki Nakayama1, Hirohito Metoki, Hiroyuki Terawaki

  • 1Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, and Ohasama Hospital, Iwate, Japan. mnakayama@mail.tains.tohoku.ac.jp

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|March 31, 2007
PubMed

Insights

Chronic kidney disease (CKD) significantly increases stroke risk in Japanese adults. Public awareness of CKD risks is crucial, especially given the high stroke prevalence in this population.

Area of Science:

  • Nephrology
  • Neurology
  • Epidemiology

Background:

  • Chronic Kidney Disease (CKD) is a known risk factor for mortality and cardiovascular disease (CVD).
  • Stroke incidence differs between Western and Asian populations, with a high prevalence of stroke in Japan.
  • The association between CKD and stroke risk in Japanese populations remains unclear.

Purpose of the Study:

  • To investigate whether CKD is a risk factor for stroke events in a general Japanese population.
  • To analyze the relationship between kidney function, macroalbuminuria, and the incidence of symptomatic stroke and all-cause mortality.

Main Methods:

  • Creatinine clearance and dipstick tests from spot-urine samples were obtained from 1977 Japanese subjects (mean age 62.9 years).
  • First symptomatic stroke events and all-cause mortality were analyzed using Cox proportional hazards regression.
  • Analyses were stratified by kidney function (creatinine clearance) and presence of macroalbuminuria, adjusted for confounding factors.

Main Results:

  • Over a mean 7.76-year follow-up, 112 first symptomatic strokes and 187 deaths occurred.
  • Decreased kidney function was associated with increased relative hazard for symptomatic stroke (RH 3.1 for Ccr<40 ml/min; RH 1.9 for Ccr 40-70 ml/min).
  • Macroalbuminuria showed a trend towards increased stroke risk (RH 1.4), though not statistically significant.

Conclusions:

  • Reduced kidney function is a significant risk factor for first symptomatic stroke in the general Japanese population.
  • The findings highlight the importance of recognizing CKD as a stroke risk factor.
  • Increased public awareness regarding CKD risks is necessary, particularly in populations with high stroke prevalence.
Abstract

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