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Updated: Jul 16, 2026

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
Published on: July 21, 2017
Potential therapeutic applications of autophagy
David C Rubinsztein1, Jason E Gestwicki, Leon O Murphy
1Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK. dcr1000@cam.ac.uk
Abstract:
Autophagy is a dynamic process of subcellular degradation, which has recently sparked great interest as it is now recognized to be involved in various developmental processes and various diseases including cancer and neurodegeneration. Autophagy can function as a cytoprotective mechanism; however, it also has the capacity to cause cell death. A better understanding of autophagy is needed to allow its manipulation for therapeutic purposes, and new insights into the molecular mechanisms of autophagy are now leading to the discovery of exciting new potential drug targets.
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