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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

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Published on: January 29, 2019

Novel concepts in radioimmunotherapy for non-Hodgkin's lymphoma

Julia Schaefer-Cutillo1, Jonathan W Friedberg, Richard I Fisher

  • 1James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA.

Oncology (Williston Park, N.Y.)
|April 3, 2007
PubMed

Tositumomab/iodine-131 tositumomab (Bexxar) and ibritumomab tiuxetan (Zevalin) are radioimmunoconjugates targeting the CD20 antigen. Both agents are approved in the United States for use in relapsed or refractory, indolent or transformed, B-cell lymphoma. These agents are well tolerated and have the highest levels of single-agent activity observed in these histologies. This review will summarize the key trials that led to approval of both I-131 tositumomab and ibritumomab tiuxetan, and then focus on four novel therapeutic concepts in radioimmunotherapy: retreatment, therapy of de novo indolent lymphoma, therapy of aggressive histologies, and incorporation in high-dose therapy programs utilizing autologous stem cell support.

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