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Related Experiment Videos

Group A Streptococcus: another resistant pathogen.

Robin LaCroix1, Anna Kathryn Rye

  • 1Greenville Hospital System, University Medical Group, Children's Hospital, Greenville, SC 29615, USA. RLaCroix@ghs.org

Southern Medical Journal
|April 3, 2007
PubMed
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Erythromycin resistance in Group A Streptococcus (GAS) has significantly increased in Greenville, SC, following greater macrolide antibiotic use. This rise necessitates ongoing monitoring to prevent treatment failures.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Erythromycin resistance in Group A Streptococcus (GAS) was minimal (<5%) in Greenville, SC, in 1992.
  • Macrolide and azalide antibiotic usage has notably increased in the Greenville area since 1992.

Purpose of the Study:

  • To re-evaluate the susceptibility patterns of pharyngeal GAS isolates to erythromycin.
  • To determine the impact of increased macrolide and azalide use on GAS resistance.

Main Methods:

  • 106 GAS isolates were collected from community pediatric offices.
  • Kirby-Bauer disk diffusion testing was employed to screen for macrolide resistance.
  • Resistance was defined using National Committee for Clinical Laboratory Standards guidelines.

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Main Results:

  • 11% of GAS isolates exhibited full resistance to erythromycin.
  • 0.9% of isolates showed intermediate resistance to erythromycin.
  • A significant increase in erythromycin resistance was observed compared to 1992 levels.

Conclusions:

  • Erythromycin resistance in GAS has markedly increased in Greenville over a decade.
  • This trend correlates with increased macrolide utilization in the community.
  • Continuous surveillance of resistance rates is crucial for clinical practice.