[New cardenolides from Convallaria majalis].

Area of Science:

• Phytochemistry
• Natural Product Chemistry
• Pharmacognosy

Context:

• Convallaria majalis L. (Lily of the Valley) is a well-known source of cardiac glycosides.
• Previous studies have identified numerous cardenolides, but ongoing research continues to uncover novel compounds.
• Understanding the chemical diversity of Convallaria majalis is important for potential pharmacological applications.

Purpose:

• To isolate and structurally elucidate new glycosides from the leaves of Convallaria majalis L.
• To identify novel natural products and expand the known chemical profile of the plant.
• To contribute to the understanding of cardenolide biosynthesis and diversity.

Summary:

• Eight glycosides derived from strophanthidin, cannogenol, sarmentogenin, and 19-hydroxysarmentogenin were isolated and characterized from Convallaria majalis leaves.
• Structural elucidation was achieved using techniques including H-NMR, EI-MS, and LD-MS.
• Notably, this study reports the first natural occurrence of 19-hydroxysarmentogenin and the first detection of an arabinosido-6-deoxyallose sugar chain in a cardiac glycoside.

Impact:

• This research expands the known repertoire of cardenolides in Convallaria majalis to 38 compounds derived from nine aglycones.
• The discovery of 19-hydroxysarmentogenin adds a new natural product to the chemical landscape of this species.
• The identification of a unique sugar moiety provides new insights into the structural diversity of cardiac glycosides.