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[The sedativ-hypnotic principle of hops]
R Hänsel1, R Wohlfart, H Schmidt
1Institut für Pharmakognosie und Phytochemie der Freien Universität Berlin.
Planta Medica
|August 1, 1982
Summary
The sedative hop constituent, 2-methyl-3-butene-2-ol, increases with storage time after drying. Pharmacologically relevant concentrations are achievable in tea and bath preparations, but not typically in marketed hop extracts or dragees.
Area of Science:
- Analytical Chemistry
- Pharmacognosy
- Organic Chemistry
Context:
- Hops (Humulus lupulus) contain numerous compounds, including 2-methyl-3-butene-2-ol, a sedative constituent.
- The concentration of 2-methyl-3-butene-2-ol in hops and hop products can vary significantly based on processing and storage.
- Understanding the stability and distribution of this compound is crucial for its potential therapeutic applications.
Purpose:
- To describe a gas chromatographic method for quantifying 2-methyl-3-butene-2-ol.
- To determine the concentration of 2-methyl-3-butene-2-ol in various hop matrices, including fresh hops, dried hops, hop extracts, and pharmaceutical preparations.
- To assess the potential for achieving pharmacologically relevant concentrations of this compound in different preparations.
Summary:
- A quantitative gas chromatographic method was developed for 2-methyl-3-butene-2-ol.
- Concentrations of 2-methyl-3-butene-2-ol increase from trace levels in fresh hops to approximately 0.15% after 2 years of room temperature storage.
- Marketed hop extracts and sedative dragees contain low levels, while sedative bath preparations show higher concentrations.
Impact:
- Pharmacologically relevant concentrations of 2-methyl-3-butene-2-ol can be achieved in hop-based tea and bath preparations.
- Further research is needed to determine if alpha-acids metabolize into 2-methyl-3-butene-2-ol in vivo, which could impact the efficacy of certain sedative products.
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